Table 2.
Cox proportional hazard ratios for total hip arthroplasty based on dietary fatty acid intake quartiles1
| Dietary Fatty Acid3 | Quartile | Univariable | BMI-Adjusted | Multivariable2 | |
|---|---|---|---|---|---|
|
| |||||
| HR (95% CI) | HR (95% CI) | HR (95% CI) | p-value4 | ||
|
| |||||
|
SFA pU= 0.861 pB= 0.923 pM= 0.688 |
Q2 | 1.04 (0.92, 1.18) | 1 (0.88, 1.13) | 1 (0.87, 1.15) | 0.535 |
| Q3 | 1.05 (0.92, 1.2) | 1 (0.87, 1.14) | 1.08 (0.94, 1.24) | ||
| Q4 | 1.05 (0.92, 1.2) | 0.96 (0.84, 1.1) | 1.03 (0.88, 1.19) | ||
|
MUFA pU= 0.883 pB= 0.514 pM= 0.936 |
Q2 | 0.99 (0.87, 1.13) | 0.97 (0.86, 1.11) | 0.99 (0.87, 1.13) | 0.577 |
| Q3 | 1.02 (0.89, 1.17) | 0.98 (0.85, 1.12) | 1.02 (0.89, 1.18) | ||
| Q4 | 0.97 (0.84, 1.11) | 0.9 (0.79, 1.04) | 1.04 (0.89, 1.2) | ||
|
PUFA pU= 0.996 pB= 0.808 pM= 0.899 |
Q2 | 0.99 (0.87, 1.13) | 0.97 (0.86, 1.11) | 1.02 (0.89, 1.17) | 0.492 |
| Q3 | 0.99 (0.87, 1.13) | 0.96 (0.84, 1.09) | 1.02 (0.88, 1.17) | ||
| Q4 | 0.98 (0.86, 1.12) | 0.94 (0.82, 1.07) | 1.06 (0.91, 1.22) | ||
|
Total n-6 pU= 0.853 pB= 0.478 pM= 0.998 |
Q2 | 0.99 (0.87, 1.12) | 0.97 (0.85, 1.1) | 1.01 (0.88, 1.16) | 0.916 |
| Q3 | 0.98 (0.86, 1.11) | 0.95 (0.83, 1.08) | 1.01 (0.88, 1.17) | ||
| Q4 | 0.94 (0.83, 1.08) | 0.9 (0.79, 1.03) | 1.01 (0.87, 1.17) | ||
|
LA pU= 0.873 pB= 0.508 pM= 0.996 |
Q2 | 0.99 (0.87, 1.13) | 0.97 (0.86, 1.11) | 1.01 (0.89, 1.16) | 0.872 |
| Q3 | 0.98 (0.86, 1.11) | 0.95 (0.83, 1.08) | 1.01 (0.88, 1.17) | ||
| Q4 | 0.95 (0.83, 1.08) | 0.9 (0.79, 1.03) | 1.01 (0.88, 1.17) | ||
|
AA pU= 0.174 pB= 0.666 pM= 0.189 |
Q2 | 1.08 (0.95, 1.23) | 1.06 (0.93, 1.21) | 1.08 (0.94, 1.24) | 0.030 |
| Q3 | 1.13 (0.99, 1.29) | 1.08 (0.95, 1.23) | 1.12 (0.97, 1.29) | ||
| Q4 | 1.15 (1.01, 1.30) | 1.07 (0.94, 1.23) | 1.16 (1.01, 1.34) | ||
|
Total n-3 pU= 0.411 pB= 0.369 pM= 0.286 |
Q2 | 0.95 (0.83, 1.08) | 0.93 (0.82, 1.06) | 0.95 (0.83, 1.1) | 0.211 |
| Q3 | 1.06 (0.93, 1.2) | 1.03 (0.91, 1.18) | 1.08 (0.94, 1.24) | ||
| Q4 | 0.98 (0.86, 1.11) | 0.95 (0.83, 1.08) | 1.05 (0.92, 1.21) | ||
|
ALA pU= 0.209 pB= 0.165 pM= 0.294 |
Q2 | 0.96 (0.84, 1.09) | 0.94 (0.82, 1.07) | 0.98 (0.85, 1.12) | 0.6 |
| Q3 | 1.06 (0.93, 1.2) | 1.03 (0.91, 1.17) | 1.1 (0.96, 1.26) | ||
| Q4 | 0.93 (0.81, 1.06) | 0.9 (0.79, 1.03) | 1 (0.87, 1.15) | ||
|
EPA+DHA pU <0.001 pB <0.001 pM= 0.023 |
Q2 | 1.06 (0.92, 1.21) | 1.06 (0.92, 1.22) | 1.01 (0.87, 1.17) | 0.003 |
| Q3 | 1.22 (1.07, 1.39) | 1.23 (1.08, 1.41) | 1.13 (0.98, 1.3) | ||
| Q4 | 1.28 (1.13, 1.46) | 1.29 (1.14, 1.48) | 1.2 (1.05, 1.39) | ||
Baseline hazard stratified by trial membership, and age was the time scale
Multivariable model contains race, BMI, physical activity, education, history of arthritis(non-rheumatoid), history of joint pain, NSAID/Aspirin use, Calcium and Vitamin D (diet + supplement), alcohol, smoking, and number of chronic conditions.
The p-values represent differences between quartiles based on model pU(univariable), pB(bmi-adjusted), pM(multivariable). Pairwise comparisons performed with Q1 as the reference quartile.
p-value for linear trend of the multivariable analysis.
Legend: HR, hazard ratio; 95% CI, 95% confidence interval; SFA, saturated fatty acids; MUFA, monounsaturated fatty acids; PUFA, polyunsaturated fatty acids; n-6, omega-6 fatty acids; LA, linoleic acid; AA, arachidonic acid; n-3, omega-3 fatty acids; ALA, alpha linolenic acid; EPA+DHA, eicosatetraenoic acid + docosahexaenoic acid.