Table 5.
Cox proportional hazard ratios for total knee arthroplasty based on quartiles of red blood cell fatty acids in WHIMS participants1
| RBC Fatty Acid | Quartile2 | Univariable | BMI-Adjusted | |
|---|---|---|---|---|
|
| ||||
| HR (95% CI) | HR (95% CI) | p-value3 | ||
|
| ||||
| SFA | Q2 | 1 (0.62, 1.62) | 0.95 (0.59, 1.54) | 0.948 |
| Q3 | 1.15 (0.77, 1.72) | 1.07 (0.71, 1.61) | ||
| Q4 | 1.07 (0.72, 1.59) | 0.96 (0.65, 1.43) | ||
| MUFA | Q2 | 1.19 (0.74, 1.91) | 1.17 (0.74, 1.86) | 0.471 |
| Q3 | 1.22 (0.81, 1.82) | 1.18 (0.79, 1.75) | ||
| Q4 | 1.4 (0.99, 2) | 1.35 (0.94, 1.93) | ||
| PUFA | Q2 | 1.03 (0.69, 1.54) | 1.08 (0.72, 1.61) | 0.488 |
| Q3 | 0.93 (0.61, 1.43) | 0.97 (0.64, 1.47) | ||
| Q4 | 0.87 (0.6, 1.28) | 0.94 (0.64, 1.37) | ||
| Total n-6 | Q2 | 1.04 (0.69, 1.56) | 1.02 (0.67, 1.54) | 0.786 |
| Q3 | 1.04 (0.69, 1.58) | 1.01 (0.65, 1.55) | ||
| Q4 | 0.96 (0.68, 1.34) | 0.96 (0.69, 1.35) | ||
| LA | Q2 | 0.96 (0.64, 1.44) | 0.96 (0.64, 1.44) | 0.785 |
| Q3 | 1.06 (0.72, 1.55) | 1.06 (0.72, 1.56) | ||
| Q4 | 0.95 (0.69, 1.33) | 1.01 (0.72, 1.42) | ||
| AA | Q2 | 1.06 (0.74, 1.51) | 1.07 (0.75, 1.53) | 0.578 |
| Q3 | 0.97 (0.67, 1.4) | 0.98 (0.68, 1.4) | ||
| Q4 | 0.96 (0.68, 1.34) | 0.97 (0.69, 1.37) | ||
| Total n-3 | Q2 | 1.18 (0.78, 1.77) | 1.21 (0.79, 1.86) | 0.47 |
| Q3 | 0.98 (0.64, 1.5) | 1.02 (0.67, 1.57) | ||
| Q4 | 0.99 (0.68, 1.43) | 1.08 (0.73, 1.58) | ||
| ALA | Q2 | 0.99 (0.67, 1.45) | 1.04 (0.71, 1.53) | 0.678 |
| Q3 | 1.01 (0.72, 1.41) | 1.08 (0.77, 1.51) | ||
| Q4 | 1.03 (0.64, 1.67) | 1.14 (0.71, 1.82) | ||
| EPA+DHA | Q2 | 1.1 (0.7, 1.72) | 1.12 (0.71, 1.77) | 0.529 |
| Q3 | 0.93 (0.64, 1.35) | 0.95 (0.65, 1.39) | ||
| Q4 | 0.94 (0.65, 1.35) | 1 (0.69, 1.45) | ||
1
Baseline hazard was stratified by trial membership, and age was the time scale.
2
Pairwise comparisons performed with Q1 as the reference quartile.
3
p-value for linear trend
Note: due to the small number of events, multivariable models are not included.
Legend: HR, hazard ratio; 95% CI, 95% confidence interval; SFA, saturated fatty acids; MUFA, monounsaturated fatty acids; PUFA, polyunsaturated fatty acids; n-6, omega-6 fatty acids; LA, linoleic acid; AA, arachidonic acid; n-3, omega-3 fatty acids; ALA, alpha linolenic acid; EPA+DHA, eicosatetraenoic acid + docosahexaenoic acid.