Table 3. Stability Studies of Opt-RUT-TE and Opt-RUT-TE Gel at Room Temperature (25 ± 2 °C/60 ± 5% RH).
| Time (months) | 0 | 2 | 4 | 6 |
| Opt-RUT-TE Gel | ||||
| Homogeneity | Homogeneous | |||
| pH | 5.89 ± 1.09 | 5.78 ± 0.87 | 5.98 ± 1.14 | 5.97 ± 0.61 |
| Color | Slightly yellowish | |||
| Spreadability | a | a | a | b |
| Extrudability | a | a | b | a |
| Opt-RUT-loaded TE | ||||
| Physical appearance | No change in appearance | |||
| Vesicle size (nm) | 161.24 ± 0.79 | 162.78 ± 1.98 | 163.54 ± 1.49 | 164.49 ± 2.01 |
| Entrapment efficiency (%) | 83.98 ± 2.49 | 83.91 ± 1.47 | 83.11 ± 2.04 | 81.78 ± 1.97 |
a
Excellent.
b
Satisfactory.