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. 2024 Jun 27;22:143. doi: 10.1186/s12915-024-01939-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Expression of common TE sensors and functional enrichment for HECs/HSCs. A, E Expression heatmap of common TE sensors in human and mouse, including RLRs, TLRs, NLRs, PKRs, DNA sensors, and downstream intermediates. B, F Gene set enrichment analysis of GO terms in human and mouse HECs/HSCs. The NES (normalized enrichment score) represents the degree to which a gene set is overrepresented at the top or bottom of a ranked list of genes. C, G Module scores of TE sensors and inflammatory genes in human and mouse. D, H Expression trends of TE silencers, TEs (HME5 and MME5, kME≥0.3), and TE sensing genes during human and mouse EHT. The expression pattern of TEs is opposite to that of TE silencers, whereas TE sensors are less active until the HSC stage