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. 2024 Jun 27;22:143. doi: 10.1186/s12915-024-01939-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Hypoxia state analysis of pre-HECs and the AGM niche. A Velocity length and cell cycle scores on the human EHT UMAP. B The proportions of spliced and unspliced RNAs in each cell type. C Gene set enrichment analysis of GO terms in human pre-HECs. D Expression of hypoxia-related genes and TE silencers in human EHT. E Co-embedding of expression of hypoxia-related genes and TE silencers. The expression patterns of the two seem to be opposite. F Spatial expression of hypoxia-related genes in the human AGM. G Expression heatmap of hypoxia-related genes, potential hypoxia-inhibited genes (TE silencers), and TEs in HME5 (kME≥0.3)