Table 3.
Significant gray matter thickness differences between HCs and CI groups, HCs and NI groups, CI and CIA groups, and NI and NOI groups
| Index | Brain regions | Side (R/L) | Size | MNI coordinate | Values | P | |||
|---|---|---|---|---|---|---|---|---|---|
| X | Y | Z | |||||||
| HCs vs CI (15 vs 26) | |||||||||
| Thickness (mm) | Medial orbitofrontal | L | 934.09 | − 11.9 | 25.2 | − 16.9 | 2.52 ± 0.18 | 2.26 ± 0.12 | < 0.001 |
| 415.82 | − 10.3 | 39.9 | − 4.2 | 2.65 ± 0.19 | 2.36 ± 0.18 | < 0.001 | |||
| Inferior parietal | L | 523.47 | − 28.9 | − 84.2 | 12.2 | 2.11 ± 0.15 | 2.34 ± 0.13 | < 0.001 | |
| 380.10 | − 39.2 | − 62.4 | 29.7 | 2.26 ± 0.15 | 2.49 ± 0.11 | < 0.001 | |||
| Lingual | L | 462.16 | − 3.7 | − 87.1 | − 5.4 | 1.96 ± 0.13 | 1.70 ± 0.11 | < 0.001 | |
| Pericalcarine | L | 332.09 | − 7.0 | − 93.7 | 8.2 | 1.97 ± 0.18 | 1.74 ± 0.18 | < 0.001 | |
| Lateral occipital | R | 1542.30 | 22.6 | − 91.7 | − 7.9 | 1.90 ± 0.06 | 1.70 ± 0.12 | < 0.001 | |
| Superior parietal | R | 423.87 | 20.2 | − 59.2 | 55.4 | 2.13 ± 0.13 | 2.33 ± 0.13 | < 0.001 | |
| HCs vs NI (15 vs 40) | |||||||||
| Thickness (mm) | Inferior parietal | L | 3835.17 | − 40.2 | − 70.0 | 14.5 | 2.21 ± 0.10 | 2.45 ± 0.08 | < 0.001 |
| Medial orbitofrontal | L | 803.98 | − 12.5 | 26.1 | − 17.1 | 2.54 ± 0.18 | 2.30 ± 0.13 | < 0.001 | |
| Supramarginal | L | 296.95 | − 52.3 | − 41.4 | 31.3 | 2.41 ± 0.20 | 2.65 ± 0.15 | < 0.001 | |
| Cuneus | L | 283.66 | − 4.9 | − 92.7 | 9.1 | 1.98 ± 0.17 | 1.81 ± 0.19 | 0.001 | |
| Lingual | L | 276.64 | − 6.8 | − 92.7 | − 10.2 | 2.11 ± 0.17 | 1.85 ± 0.20 | < 0.001 | |
| Superior parietal | L | 382.95 | − 16.9 | − 65.1 | 50.2 | 2.12 ± 0.12 | 2.39 ± 0.15 | < 0.001 | |
| R | 233.91 | 29.3 | − 49.0 | 63.5 | 2.20 ± 0.16 | 2.43 ± 0.20 | < 0.001 | ||
| Pericalcarine | R | 644.63 | 8.9 | − 72.8 | 5.7 | 1.80 ± 0.12 | 1.59 ± 0.14 | < 0.001 | |
| CI vs CIA (26 vs 24) | |||||||||
| Thickness (mm) | Medial orbitofrontal | R | 226.42 | 5.9 | 47.1 | − 18.3 | 2.38 ± 0.17 | 2.67 ± 0.29 | < 0.001 |
| NI vs NOI (40 vs 30) | |||||||||
| Thickness (mm) | Pericalcarine | R | 705.06 | 23.5 | − 69.5 | 4.0 | 1.62 ± 0.16 | 1.50 ± 0.15 | 0.002 |
R Right, L Left, MNI Montreal Neurological Institute, HCs Healthy controls, CI Patients with a history of chronic insomnia whose sleep status did not change after infection, CIA Patients with a history of chronic insomnia whose insomnia symptoms worsened after infection, NI Individuals with good sleep quality who had no change in sleep status after infection, NOI Individuals with good sleep quality who experienced a new onset of insomnia after infection