Table 2.
Generalized linear modelsa evaluating the odds of KCO < 80% and FEV1 < 80% in PI*SS compared to PI*ZZ subjects
| Variable | Univariable analysis | Multivariable analysisb | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P-value | Adjusted OR | 95% CI | P-value | |
| KCO(%) < 80% | ||||||
| Unmatched cohort (N = 634) | 0.51 | 0.30 to 0.89 | 0.019 | 0.51 | 0.28 to 0.91 | 0.022 |
| Matched cohort (N = 185) | 0.30 | 0.15 to 0.59 | 0.001 | 0.29 | 0.14 to 0.57 | < 0.001 |
| FEV1(%) < 80% | ||||||
| Unmatched cohort (N = 634) | 0.69 | 0.40 to 1.21 | 0.195 | 0.70 | 0.39 to 1.23 | 0.242 |
| Matched cohort (N = 185) | 0.31 | 0.16 to 0.61 | 0.001 | 0.30 | 0.15 to 0.62 | 0.001 |
Abbreviations: FEV1(%): Forced expiratory volume in one second in percent predicted; KCO(%): Carbon monoxide transfer coefficient in percent predicted; OR: odds ratio; CI: confidence interval
a Generalized estimating equations used to estimate the parameters of the generalized linear models, considering a binomial distribution and accounting for the effect raised by the clustering of patients from the same centre. b Adjusted for number of total exacerbations in the last year and previous pneumonia