Fig. 7.

VPS50 mKO animals show impaired hippocampal memory formation. Brain-wide control and VPS50 mKO animals were subjected to behavioral testing. A Quantification of the time spent on the ramp on the accelerated rotarod apparatus. B Scheme of the Barnes maze memory paradigm in which clues attached to the wall, escape hole, and escape zone are shown. C Quantification of the numbers of primary errors made by control and VPS50 mKO animals before finding the escape hole. D Quantification of the primary latency of control and VPS50 mKO animals to find the escape hole. E Quantification of the time control and VPS50 mKO animals spent in the escape zone. F Quantification of freezing percentage time shown by control and VPS50 mKO animals in the fear conditioning paradigm. For behavioral experiments, a total of N = 13 animals per condition were assayed. Unpaired t-test was used for statistical analysis; *p < 0.05. Error bars represent ± SEM