Fig. 7. Immunogenic epitopes.

Immunogenic B cell epitopes identified in an MSP-1 vaccine trial (9) are mapped onto MSP-1. On the basis of correlation between IgG responses and parasite growth inhibition assay (GIA) activity of the various investigated sera, Blank et al. (9) identified epitopes putatively associated with GIA activity. Blue, no role; red, possible role in inhibiting parasite growth. Colored ovals indicate the degree of sequence conservation for each epitope: Dark purple, light purple, white, and green correspond to conserved, semiconserved (>50% conserved residues, rest dimorphic), mostly dimorphic (<50% conserved residues, rest dimorphic), and nonconserved epitopes. Dotted lines represent unresolved loops (scaled 1/3.5 relative to ribbon). More details can be found in fig. S9. aa, amino acids.