TABLE 1.
TP53 and PIK3CA somatic mutation frequencies
| Study | Total N | TP53 Mutation N (%) | TP53 subtype N (%) | PIK3CA Mutation N (%) | PIK3CA subtype N (%) |
|---|---|---|---|---|---|
| Discovery | 2,850 | 879 (31%) | GOF 237 (8%) | 1,095 (38%) | Activating 858 (30%) |
| LOF 536 (19%) | p.E542K 112 (4%) | ||||
| Unknown 106 (4%) | p.E545K 193 (7%) | ||||
| p.1047R/L 387 (14%) | |||||
| Validation | 1,285 | 414 (40%) | GOF 110 (11%) | 290 (28%) | Activating 235 (23%) |
| LOF 277 (27%) | p.E542K 40 (4%) | ||||
| Unknown 27 (3%) | p.E545K 58 (6%) | ||||
| p.H1047R/L 133 (13%) | |||||
| MyBrCa | 859 | 369 (43%) | GOF 114 (13%) | 247 (29%) | Activating 217 (25%) |
| LOF 241 (28%) | p.E542K 20 (2%) | ||||
| Unknown 14 (2%) | p.E545K 55 (6%) | ||||
| p.H1047R/L 115 (13%) | |||||
| B-CAUSE | 393 | 365 (93%) | GOF 85 (22%) | 9 (2%) | Activating 4 (1%) |
| LOF 260 (66%) | p.H1047R/L 2 (0.5%) | ||||
| Unknown 20 (5%) |
Abbreviations: N, number; %, percent of total number.