FIG. 5.
Graphs show the histology of the rats’ liver in the control, 2–3-week, 6–8-week, and 11–16-week groups, respectively: Masson’s trichrome-stained sections of liver for collagen (blue/green) from CCl4-induced injury. The degree of fibrosis increases from normal in control rats (upper left) to minimal in the 2–3-week group (upper right), to mild and moderate in the 6–8-week group (bottom left), and finally to marked and severe in the 11–16-week group (bottom right). Rats in the 6–8-week group (bottom left) had the most significant fatty change (steatosis) within hepatocytes. Rats in the 11–16-week group (bottom right) had nodular hepatocellular regeneration (NR), marked fibrosis (*) that bridged hepatic lobules and pronounced biliary hyperplasia (BH), which indicate cirrhosis. Scale bars = 200 μm.