Table 5.
Drug susceptibility to other antifungal drugs
| Author | Number of isolates | MIC method | Micafungin | Anidulafungin | Caspofungin | Amphotericin B | Flucytosine |
|---|---|---|---|---|---|---|---|
| Al-obaid et al. 58 | 63 | Vitek 2 YST AST/CLSI BPs | R: 0, 0% Range: 0.06–0.06 MIC50: 0.06 MIC90: 0.06 |
Not done | R: 0, 0% Range: 0.25–0.25 MIC50: 0.25 MIC90: 0.25 |
NWT: 0, 0% Range: 0.25–0.5 MIC50: 0.25 MIC90: 0.5 |
R: 1, 1.6% Range: 1.0–16 MIC50: 1 MIC90: 1 |
| Arastehfar, Daneshnia, et al. 1 | 64 | CLSI M27-A3 | R: 2, 3.1% GM: 0.05 Range: 0.008–1 MIC50: 0.06 MIC90: 0.25 |
R: 0, 0% GM: 0.04 Range: 0.008–0.5 MIC50: 0.025 MIC90: 0.125 |
Not done | NWT: 0, 0% GM 0.64 Range: 0.125–2 MIC50: 0.5 MIC90: 1 |
Not done |
| Arastehfar et al. 21 | 161 | CLSI M27-A3 | R: 0, 0% | R: 0, 0% | Not done | NWT: 0, 0% | Not done |
| Castanheira et al. 26 | 227 | CLSI M27-A3 | R: 2, 0.9% | R: 2, 0.9% | R: 2, 0.9% | NWT: 0, 0% | Not done |
| Chapman et al. 16 | 24 | Sensititre YeastOne/CLSI BPs | R: 0, 0% GM: 0.02 Range: <0.008–0.06 MIC90: 0.03 |
R: 0, 0% GM: 0.03 Range: <0.015–0.12 MIC90: 0.06 |
R: 0, 0% GM: 0.04 Range: 0.015–0.25 MIC90: 0.09 |
NWT: 0, 0% GM: 0.65 Range: <0.12–1 MIC90: 1 |
NWT: 1, 4% GM: 0.07 Range: <0.06–1 MIC90: 0.197 |
| Chen et al. 31 | 344 | Sensititre YeastOne/CLSI BPs | R: 2, 0.6% Range: 0.015–2 MIC50: 0.03 MIC90: 0.03 |
R: 2, 0.6% Range: 0.008–1 MIC50: 0.06 MIC90: 0.12 |
R: 3, 0.9% Range: 0.015–8 MIC50: 0.06 MIC90: 0.12 |
NWT: 0, 0% Range: 0.25–1 MIC50: 1 MIC90: 1 |
NWT: 4, 1.2% Range: 0.03–64 MIC50: 0.03 MIC90: 0.06 |
| Fan et al. 32 | 585 | Sensititre YeastOne/CLSI BPs | R: 2, 0.4% I: 0, 0% GM: 0.03 MIC50: 0.03 MIC90: 0.03 |
R: 2, 0.4% I: 2, 0.4% GM: 0.07 MIC50: 0.06 MIC90: 0.25 |
R: 2, 0.4% I: 0, 0% GM: 0.04 MIC50: 0.03 MIC90: 0.06 |
NWT: 0, 0% GM: 0.75 MIC50: 1 MIC90: 1 |
NWT: 3, 0.6% GM: 0.07 MIC50: 0.03 MIC90: 0.12 |
| Fernández-Ruiz et al. 11 | 56 | EUCAST broth microdilution | GM: 0.034 MIC90: 0.03 |
R: 2, 3.6% GM: 0.034 MIC90: 0.03 |
GM: 0.41 MIC90: 0.5 |
R: 0, 0% GM: 0.079 MIC90: 0.12 |
Not done |
| Guinea et al. 48 | 59 | EUCAST and CLSI M27-A3 | EUCAST GM: 0.034 MIC90: 0.03 Range: ≤0.03–2 CLSI R: 2, 3.4% GM: 0.021 MIC90: 0.06 Range: 0.03–1 |
EUCAST R: 2, 3.4% GM: 0.034 Range: ≤0.03–1 MIC90: 0.03 CLSI R: 2, 3.4% GM: 0.014 Range: 0.017–2 MIC90: 0.03 |
EUCAST GM: 0.41 Range:0.12–2 MIC90: 0.5 CLSI R: 0, 0% I: 1, 1.7% GM: 0.12 Range: 0.015–0.5 MIC90: 0.25 |
EUCAST GM: 0.079 Range: ≤0.03–0.5 MIC90: 0.12 CLSI GM: 0.22 Range: 0.03–1 MIC90: 0.5 |
EUCAST GM: 0.154 Range: ≤0.12–32 MIC90: 0.12 |
| Guo et al. 39 | 160 | CLSI M27-A3 | R: 0, 0% Range: 0.008–0.25 MIC50: 0.32 MIC90: 0.125 |
Not done | R: 0, 0% I: 9, 5.6% Range: 0.008-0.5 MIC50: 0.125 MIC90: 0.25 |
NWT: 0, 0% Range: 0.125–2 MIC50: 0.5 MIC90: 1 |
NWT: 0, 0% Range: 0.064–0.125 MIC50: 0.064 MIC90: 0.064 |
| Katsuragi et al. 35 | 11 | CLSI M27-A3 | Range: 0.06–2 MIC50: 0.06 MIC90: 0.13 |
Not done | Not done | Range: 0.13–1 MIC50: 0.25 MIC90: 0.5 |
NWT: 0, 0% Range: 0.13–4 MIC50: 0.25 MIC90: 0.25 |
| Liu et al. 10 | 248 | Sensititre YeastOne/CLSI BPs | R: 4, 1.6% I: 2, 0.8% Range: 0.015–2 MIC50: 0.03 MIC90: 0.03 |
R: 4, 1.6% I: 1, 0.4% Range: 0.03–2 MIC50: 0.12 MIC90: 0.25 |
R: 4, 1.6% I: 2, 0.8% Range: 0.015–>8 MIC50: 0.06 MIC90: 0.25 |
NWT: 0, 0% Range: 0.12–2 MIC50: 0.5 MIC90: 1 |
NWT: 3, 1.2% Range: <0.06–64 MIC50: 0.06 MIC90: 0.12 |
| Medeiros et al. 27 | 12 | CLSI M27-A3 | R: 0, 0% Range: <0.015–1.0 MIC50: <0.015 MIC90: 0.03 |
Not done | Not done | R: 0, 0% Range: 0.06–1.0 MIC50: 0.25 MIC90: 1.0 |
Not done |
| Megri et al. 4 | 19 | CLSI M27-A3 | R: 0, 0% | R: 0, 0% | Not done | NWT: 0, 0% | Not done |
| Siopi et al. 28 | 23 | Sensititre YeastOne/CLSI BPs | R: 0, 0% Range: 0.015–0.06 MIC50: 0.03 MIC90: 0.06 |
R: 0, 0% Range: ≤0.015–0.12 MIC50: ≤0.015 MIC90: 0.06 |
R: 0, 0% Range: 0.015–0.12 MIC50: 0.03 MIC90: 0.06 |
Not done | NWT: 0, 0% Range: ≤0.06–0.12 MIC50: ≤0.06 MIC90: 0.12 |
| Tasneem et al. 29 | 26 | CLSI M44-A disk diffusion | Not done | Not done | Not done | NWT: 0, 0% | Not done |
| Xiao et al. 30 | 379 | Sensititre YeastOne/CLSI BPs | R: 0, 0% GM: 0.03 Range: ≤0.008–0.06 |
R: 0, 0% I: 11, 0.3% GM: 0.05 Range: ≤0.015–0.5 |
R: 0, 0% GM: 0.04 Range: 0.15–0.25 |
NWT: 0, 0% GM: 0.68 Range: 0.25–1 |
NWT: 3, 1.1% GM: 0.04 Range: ≤0.06→64 |
Note: Susceptibility values are expressed as minimum inhibitory concentrations (MICs) in mg/L. BPs, breakpoints, GM, Geometric mean, MIC50, minimum inhibitory concentration of 50% of isolates, MIC90, minimum inhibitory concentration of 90% of isolates; S, susceptible; SDD, susceptible dose dependent; I, intermediate; R, resistant; WT, wildtype; NWT, non-wild type. Data are given as provided in source documents.