Table 2.

Quality Assessment for All 12 Included Studies

(A) RCTs
		Internal Validity
		Selection and Allocation			Administration of Intervention			Assessment, Detection, and Measurement of Outcome			Participant Retention	Statistical Validity
Citation	Outcome	1	2	3	4	5	6	7	8	9	10	11	12	13
Cehajic-Kapetanovic et al.18	Number of retinotomies	Yes	Yes	Yes	Unclear	No	Yes	Unclear	Yes	Unclear	Yes	No	Yes	Yes
	Volume of tPA injected	—	—	—	—	—	—	Unclear	Yes	Yes	Yes	No	Yes	—
	Duration of tPA injection	—	—	—	—	—	—	Unclear	Yes	Yes	Yes	No	Yes	—
	Duration of surgery	—	—	—	—	—	—	Unclear	Yes	Yes	Yes	No	Yes	—
	BCVA	—	—	—	—	—	—	Unclear	Yes	Yes	Yes	No	Yes	—
	Successful displacement of submacular hemorrhage	—	—	—	—	—	—	Unclear	Yes	Unclear	Yes	No	Yes	—
	Frequency of microtraumatic events	—	—	—	—	—	—	Yes	Yes	Yes	Yes	No	Yes	—
Edwards et al.8	Surgical success	Yes	Yes	Yes	Unclear	No	No	Unclear	Yes	Unclear	Yes	Yes	N/A	Yes
	Duration of surgery	—	—	—	—	—	—	No	Yes	Yes	Yes	Yes	Yes	—
	Time required to position instrument	—	—	—	—	—	—	No	Yes	Yes	Yes	Yes	Yes	—
	Time required to initiate membrane flap	—	—	—	—	—	—	No	Yes	Yes	Yes	Yes	Yes	—
	Frequency of microtraumatic events	—	—	—	—	—	—	No	Yes	Unclear	Yes	Yes	Yes	—
	Surgeons’ descriptive experiences	—	—	—	—	—	—	No	Yes	Unclear	Yes	Yes	N/A	—
Faridpooya et al.20	Feasibility	No	No	Yes	No	No	Yes	Unclear	Yes	Unclear	Yes	No	N/A	Yes
	Duration of surgery (and substeps)	—	—	—	—	—	—	Unclear	Yes	Yes	Yes	No	N/A	—
	Mean distance traveled by forceps	—	—	—	—	—	—	Unclear	Yes	Yes	Yes	No	N/A	—
	Change in BCVA	—	—	—	—	—	—	Unclear	Yes	No	Yes	No	N/A	—
	Change in central retinal thickness	—	—	—	—	—	—	Unclear	Yes	Unclear	Yes	No	N/A	—
	Frequency of adverse events	—	—	—	—	—	—	Unclear	Yes	Unclear	Yes	No	N/A	—
(B) Case series
Citation	1	2	3	4	5	6	7	8	9	10
Bourcier et al.17	No	Unclear	Unclear	Yes	Yes	Yes	Yes	Yes	No	Yes
Cereda et al.19	No	No	Unclear	Unclear	Yes	Yes	Yes	Yes	No	Not applicable
Gijbels et al.21	No	Unclear	Unclear	Unclear	Unclear	No	No	No	No	Not applicable
Mattheis et al.23	No	Yes	Unclear	Unclear	Yes	Yes	Yes	Yes	No	Not applicable
Turgut et al.24	No	Unclear	Unclear	Unclear	Yes	No	No	No	No	Not applicable
Wang et al.7	Yes	Yes	Unclear	Unclear	Yes	Yes	Yes	Yes	No	Yes
Willekens et al.25	Yes	Yes	Yes	Unclear	Yes	Yes	Yes	Yes	No	Yes
(C) Case reports
Citation	1	2	3	4	5	6	7	8
Bourcier et al.9	No	No	Yes	Yes	Yes	No	No	Yes
Jeannon et al.22	Yes	Unclear	Yes	Yes	Yes	Unclear	No	Yes

Joanna Briggs Tools for Critical Appraisal were used for quality assessment; different instruments were employed for each study design observed. Quality of reporting ranged from fair to good, but sample size was ubiquitously low. BCVA, best-corrected visual acuity.