Table. Distribution of α2,3 and α2,6 receptors with influenza A virus nucleoprotein in the respiratory tract and mammary gland of US dairy cattle naturally infected with highly pathogenic avian influenza A(H5N1) virus*.
| Site | MAL-I | MAL-II | SNA | IAV-Np |
|---|---|---|---|---|
| Respiratory tract | ||||
| Tracheal epithelium | + (mem, goblet) | + (mem, goblet) | +/− (goblet) | – |
| Bronchial epithelium | + (mem, goblet) | + (mem, goblet) | – | – |
| Bronchiolar epithelium | + (mem) | + (mem) | – | – |
| Pneumocytes, alveolus |
+ (mem) |
+ (mem) |
– |
– |
| Mammary gland | ||||
| Glandular epithelium | – | + (mem) | + (mem) | + (IN, IC) |
| Interlobular ductal epithelium | – | – | + (mem) | + (IN, IC) |
*Goblet, goblet cells; IC, intracytoplasmic; IN, intranuclear; IAV-Np, influenza A virus nucleoprotein; MAL, Maackia amurensis lectin; mem, membranous; SNA, Sambucus nigra lectin; –, no labeling observed; +, positive labeling. †α2,3-gal-β (1–4) N-acetylglucosamine. ‡α2,3-gal-β (1–3) N-acetylgalactosamine. §α2,6-gal.