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. 2024 Mar 5;20(6):1213–1246. doi: 10.1080/15548627.2024.2319901

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© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 4. — Lipophagy in ferroptosis. Lipophagy refers to the autophagic clearance of lipid droplets, which function as storage organelles for neutral lipids. RAB7A, associated with lipid droplets, drives lipophagy and promotes subsequent ferroptosis. The formation of lipid droplets, mediated by TPD52 and PLTP, antagonizes lipophagy-dependent ferroptosis. In contrast, PGRMC1 triggers lipophagy-dependent ferroptosis. PUFA, polyunsaturated fatty acid.