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. Author manuscript; available in PMC: 2024 Jun 27.
Published in final edited form as: Curr Trop Med Rep. 2023 Oct 25;10(4):222–234. doi: 10.1007/s40475-023-00304-w

Table 2.

Comparison of clinical manifestation of rHAT and gHAT

Clinical feature/condition Gambiense human African trypanosomiasis Rhodesiense human African trypanosomiasis
Winterbottom’s sign Prominent Minimal
Trypanosomal chancre Rarely observed Common
Myocarditis Common Less common
Endocrine disorders Common Less common
CNS Chronic (late CNS disease) Acute (early CNS disease)
Duration of illness Months to years < 9 months