Table 3.

Algorithm on the management of gHAT according to WHO guidelines

Characteristics of the patient	Severe HAT suspected	CSF findings	First choice treatment
≥ 6 years old, AND ≥ 20 kg body weight	No	Lumbar puncture not indicated	Fexinidazole
	Yes	≥ 100 WBC/μL	NECT
		< 100 WBC/μL	Fexinidazole
		Lumbar puncture not done	Fexinidazole
< 6 years old, OR < 20 kg body weight (fexinida zole contraindicated)	Lumbar puncture always indicated	≤ 5 WBC/μL, no CSF tryps	Pentamidine
		6–99 WBC/μL or CSF tryps	NECT
		LP not done