Table 3.

Univariate and multivariate analyses for overall survival

	Univariate analysis			Multivariate analysis
	Hazard ratio	95% CI	p value	Hazard ratio	95% CI	p value
ECOG PS 0 vs. ≥ 1	0.61	0.47–0.81	0.001	0.69	0.52–0.93	0.016
< vs. ≥ 65 years of age	0.76	0.58–1.00	0.057	0.80	0.58–1.10	0.174
LDH N vs. > ULN	0.52	0.39–0.70	< 0.001	0.56	0.42–0.75	< 0.001
Primary tumor	0.47	0.28–0.77	0.020	0.57	0.33–1.00	0.071
Line of treatment before ICI (3 or more)	1.11	0.80–1.54	0.498
OA-untreated vs. OA-treated	0.60	0.45–0.80	< 0.001	0.58	0.43–0.79	< 0.001

ECOG PS: Eastern Cooperative Oncology Group performance score, LDH lactate dehydrogenase, ULN upper limit of the normal range