Figure 2.

Expression of PACER/COX2/PGE2 and inflammatory factors in IL1‐β + OA‐CHs. (A) Proliferation activity of CHs in IL1‐β + OA‐CHs; (B) expression level of PACER in IL1‐β + OA‐CHs; (C) expression level of PGE2 and inflammatory factors (TNF‐α, IL‐1β, IL‐4, IL‐10) in IL1‐β + OA‐CHs; (D) COX2 protein level in IL1‐β + OA‐CHs. Scale bar: 200 µm. N = 8, unpaired Student's t test. CH, chondrocyte; IL‐1β, interleukin‐1β; OA, osteoarthritis; PACER, p50‐associated cyclooxygenase 2‐extragenic RNA; TNF‐α, tumor necrosis factor‐α. ****p < .0001.