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. 2024 Jun 14;15:1419951. doi: 10.3389/fimmu.2024.1419951

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Copyright © 2024 Bidgood, Keating, Doggett and Nicholson

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The role of SOCS1 in regulating tumor immunity. Downregulation of expression or loss of SOCS1 function has been observed in certain cancer subtypes (left panel). SOCS1 can confer resistance to immune checkpoint blockade via inhibition of IFNγ signaling and down-regulation of immune checkpoints PD-L1/2 (center panel). In addition, SOCS1 limits anti-tumor immunity through various immune cell types (right panel). Figure created with BioRender.com.