Table 1.
SOCS1 induction in response to various cytokines.
| Cytokine | JAKS | Cell type | SOCS1 detection* | Reference | |
|---|---|---|---|---|---|
| Human | Rodent | ||||
| JAK/STAT cytokines that induce SOCS1 and are regulated by SOCS1 # | |||||
| IFNα/β | JAK1 TYK2 |
Huh-7, A-357, HT-144 cells; epidermal melanocytes | BMDMs |
|
(35, 37, 47–49) |
| IFNλ | JAK1 TYK2 |
Huh-7, A-549 cells |
|
(37, 48, 50) | |
| IFNγ | JAK1 JAK2 |
Huh-7 cells | BM; BMDMs; MEFs; colonic epithelial cells |
|
(13, 35, 38, 39, 48, 49) |
| IL-2 | JAK1 JAK3 |
T cells | T cells |
|
(41, 42, 51) |
| IL-4 | JAK1 JAK3 |
Osteoarthritic chondrocytes; A-549, U-937 cells |
BMDMs; T cells; MEFs; colonic epithelial cells; CT.4S cells |
|
(14, 39, 52–56) |
| IL-7 | JAK1 JAK3 |
CD8+ T cells; B cells | CD8+ T cells; B cells; T cells |
|
(42, 44, 57, 58) |
| IL-12 | JAK2 TYK2 |
T cells; BMDCs |
|
(36, 59) | |
| IL-13 | JAK1 TYK2 |
U-937 cells | TGMBE-02–3 cells; MEFs; BM; lung |
|
(13, 43, 52, 56) |
| IL-15 | JAK1 JAK3 |
CD8+ T cells; T cells |
|
(40–42) | |
| IL-21 | JAK1 JAK3 |
CD8+ T cells; DCs | CD8+ T cells |
|
(60–62) |
| JAK/STAT cytokines that induce SOCS1 but are not known to be regulated by SOCS1 | |||||
| EPO | JAK2 | BM; 32D, HCD-57 cells |
|
(13, 15) | |
| G-CSF | JAK2 | NFS-60 cells |
|
(14) | |
| GM-CSF | JAK2 | BM |
|
(13) | |
| GH | JAK2 | 3T3-F442A cells |
|
(63) | |
| IL-3 | JAK2 | BM |
|
(13) | |
| IL-6 | JAK1 JAK2 |
CD4+ T cells; BMDMs; liver; MH60.BSF2 and M1 cells |
|
(13–15, 64) | |
| IL-23 | JAK2 TYK2 |
T cells |
|
(65) | |
| IL-27 | JAK1 JAK2 |
CD8+ and CD4+ T cells |
|
(66–68) | |
| LIF | JAK1 JAK2 |
M1 cells |
|
(14) | |
| PRL | JAK2 | T-47D cells | Liver |
|
(69) |
| TSH | JAK1 JAK2 |
Endometrial stromal cells | FRTL-5 cells |
|
(70, 71) |
* indicates detection of SOCS1 mRNA or protein .
# as evidenced by SOCS1-deficient cells.
MEFs, mouse embryonic fibroblasts; BM, bone marrow; BMDMs, bone marrow-derived macrophages; DCs, dendritic cells.