Table 2.
Primary and secondary outcomes
| Outcome | Standard prone position group (n = 674) | Intensive prone position group (n = 79) | All patients (n = 753) | p |
|---|---|---|---|---|
| Primary outcome | ||||
| Mortality at 60-day, n (%) | 261 (39%) | 31 (39%) | 292 (39%) | 0.93 |
| Secondary outcomes | ||||
| Mortality, n (%) | ||||
| At day 28 | 230 (34%) | 28 (35%) | 258 (34%) | 0.82 |
| At day 90 | 262 (39%) | 31 (39%) | 293 (39%) | 0.95 |
| Ventilator-free days until day 28, median [IQR] | 2 [0; 14] | 0.5 [0; 12] | 1.5 [0; 14] | 0.74 |
| Extracorporeal membrane oxygenation, n (%) | 68 (10%) | 7 (9%) | 75 (10%) | 0.75 |
| Inhaled nitric oxide, n (%) | 161 (24%) | 24 (30%) | 185 (25%) | 0.21 |
| Neuromuscular blockers, n (%) | 652 (97%) | 74 (94%) | 726 (96%) | 0.19 |
| Renal replacement therapy, n (%) | 195 (29%) | 22 (28%) | 217 (29%) | 0.83 |
| Static compliance (mL/cmH2O), median [IQR] | ||||
| At Day-3 | 34 [25; 42] | 29 [23; 36] | 34 [25; 42] | 0.03 |
| At Day-5 | 32 [25; 40] | 28 [21; 35] | 31 [25; 40] | 0.03 |
| At Day-7 | 31 [24; 41] | 29 [21; 37] | 31 [23; 41] | 0.11 |
| SOFA score, median [IQR] | ||||
| At Day-7 | 10 [7; 12] | 9 [7; 11] | 10 [7; 12] | 0.23 |
| At Day-21 | 9 [7; 10] | 5 [5; 12] | 9 [5; 10] | – |
| At 28-day | 7 [6; 10] | 11 [11; 11] | 7 [7; 11] | – |
| PaO2/FiO2 ratio (mmHg), median [IQR] | ||||
| At Day-3 | 151 [110; 198] | 131 [105; 185] | 148 [110; 195] | 0.04 |
| At Day-5 | 144 [105; 194] | 134 [101; 209] | 144 [105; 195] | 0.54 |
| At Day-7 | 149 [108; 189] | 154 [108; 207] | 150 [108; 192] | 0.27 |
IQR: interquartile range; SOFA: sequential organ failure assessment; PaO2: arterial partial pressure in oxygen; FiO2: fraction inspired in oxygen; ICU: intensive care unit