Table 1.
Characteristics of the hip fracture cohort stratified by delirium-status
| All | No delirium | Delirium | P | |
|---|---|---|---|---|
| N | 279 | 139 | 140 | |
| Age | 84 (74; 89) | 77 (69; 86) | 87 (81; 91) | 3.7*10−12 |
| Female sex, n (%) | 192 (68.8) | 99 (71.2) | 93 (66.4) | 0.37 |
| Dementia, n (%) | 118 (42.1) | 19 (16.1) | 99 (83.9) | 5.2*10−22 |
| IQCODE | 3.3 (3.0; 4.2) | 3.1 (3.0; 3.3) | 3.9 (3.4; 4.8) | 2.0*10−15 |
| ASA III-IV, n (%) | 145 (52.0) | 54 (38.8) | 91 (65.0) | 1.4*10−14 |
| MMP-2 (ng/mL) | 59.3 (49.3; 69.4) | 56.8 (47.3; 65.0) | 62.2 (52.5; 73.5) | 0.001 |
| MMP-3 (pg/mL) | 227 (154; 335) | 205 (147; 299) | 251 (177; 360) | 0.008 |
| MMP-10 (pg/mL) | 24.2 (13.5; 41.3) | 19.2 (10.3; 31.8) | 32.4 (17.9; 45.7) | 4.7*10−6 |
| MMP-12 (pg/mL) | 3.6 (0.4; 6.7) | 3.6 (0.4; 7.8) | 3.6 (0.4; 6.7) | 0.59 |
| TIMP-1 (ng/mL) | 87.3 (66.3; 110.0) | 82.3 (60.5; 103.3) | 92.1 (72.7; 121.0) | 0.001 |
| TIMP-2 (ng/mL) | 80.4 (69.0; 93.7) | 76.2 (66.1; 87.3) | 85.7 (71.1; 99.3) | 1.2*10−4 |
| TIMP-3 (ng/mL) | 15.7 (14.4; 17.0) | 15.6 (14.1; 16.7) | 15.9 (14.4; 17.4) | 0.03 |
| TIMP-4 (ng/mL) | 1.6 (1.3; 1.9) | 1.6 (1.4; 2.0) | 1.5 (1.2; 1.9) | 0.01 |
Data is presented as median (quartile 1; quartile 3) unless otherwise indicated. P value is for comparison between patients with and without delirium using Mann Whitney U test (continuous variables) or χ2-test (categorical variables).
ASA American Society of Anesthesiologists physical status classification, IQCODE Informant Questionnaire on Cognitive Decline in the Elderly, MMP matrix metalloproteinase, TIMP tissue inhibitor of matrix metalloproteinase.