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. 2024 Jun 27;15:5441. doi: 10.1038/s41467-024-49854-1

Fig. 3. OTUD5CKO exacerbates podocyte injury and DKD in T1DM mice.

Fig. 3

a Weekly monitoring of blood glucose levels in mice. Data are presented as mean ± SD. The levels of serum creatinine (b), urea nitrogen (c), and urine albumin to creatinine ratio (d) were analyzed in mice. e, f Representative images of H&E, PAS, and TEM in mice. Scale bar: black 20 μm, red 1 μm. (n = 6 samples). Quantification of GBM thickness (g) and podocyte foot process numbers (h, i) in the glomeruli. j Representative IF images of Nephrin expression in glomeruli from mice. Scale bar, 20 μm. (n = 6 samples). Real-time qPCR showing mRNA levels of Il6 (k) and Tnfα (l) in the kidney tissues of each group. n =6 for each group. For b–d, g–i, k, and l, P values were determined by one-way ANOVA with Bonferroni’s correction, and data are presented as mean ± SD.