Table 3.
Associations of enrolment biomarkers with recurrent shock and respiratory distress.
| Enrolment value | Recurrent shock |
Respiratory distress |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No (N = 74) | Yes (N = 16) | OR | 95% CI | P-value | No (N = 80) | Yes (N = 10) | OR | 95% CI | P-value | |
| Hyaluronan (log2 ng/ml) | 11.17 (10.36, 11.99) | 11.24 (10.42, 11.81) | 1.32 | 0.78, 2.33 | 0.320 | 11.19 (10.35, 12.07) | 11.24 (10.55, 11.60) | 1.12 | 0.64, 2.04 | 0.706 |
| Syndecan-1 (log2 ng/ml) | 9.80 (9.15, 10.77) | 10.21 (9.47, 10.88) | 1.82 | 1.07, 3.35 | 0.038 | 9.85 (9.24, 10.76) | 9.89 (9.14, 11.25) | 1.35 | 0.76, 2.59 | 0.323 |
| Ferritin (log2 ng/ml) | 11.43 (10.90, 12.24) | 11.20 (10.63, 12.25) | 1.45 | 0.81, 2.74 | 0.223 | 11.40 (10.89, 12.23) | 11.55 (10.62, 12.99) | 1.66 | 0.86, 3.45 | 0.143 |
| ST-2 (log2 ng/ml) | 6.51 (5.87, 7.10) | 6.62 (5.83, 7.17) | 1.47 | 0.76, 3.04 | 0.266 | 6.53 (5.80, 7.09) | 6.40 (6.29, 7.58) | 1.71 | 0.79, 4.07 | 0.197 |
| ANP (log2 pg/ml) | 10.37 (9.77, 10.90) | 10.02 (9.74, 10.66) | 0.65 | 0.29, 1.45 | 0.297 | 10.32 (9.75, 10.75) | 10.80 (10.01, 11.15) | 1.84 | 0.73, 5.06 | 0.212 |
| NT-proBNP (log2 pg/ml) | 0.88 (-1.50, 1.94) | −1.43 (-3.06, 0.36) | 0.78 | 0.60, 1.00 | 0.071 | 0.47 (-1.74, 1.86) | −0.27 (-1.71, 0.55) | 0.95 | 0.71, 1.24 | 0.696 |
Data are presented as median (IQR). All biomarker levels are transformed using log-2. All analyses were based on logistic regression with recurrent shock or respiratory distress as the outcome, the log 2 of biomarker as the covariate, adjusted for illness day at presentation with shock. ST-2, suppression of tumourigenicity 2; ANP, atrial natriuretic peptide; NT-proBNP: N-terminal pro brain natriuretic peptide; OR: odds ratio; CI: confidence interval.