Table 1.
Mean 5-fold cross-validation performance for the prediction of ZIP synergy scores, in terms of Spearman Correlation Coefficient (SCC), Pearson Correlation Coefficient (PCC), and Mean Squared Error (MSE) for unseen cell lines (1) and unseen drug combinations (2).a
| Model | Setting (1) |
Setting (2) |
||||
|---|---|---|---|---|---|---|
| SCC ↑ | PCC ↑ | RMSE ↓ | SCC ↑ | PCC ↑ | RMSE ↓ | |
| CODEX | 0.752 (±0.004) | 0.889 (±0.005) | 5.31 (±0.18) | 0.725 (±0.005) | 0.877 (±0.005) | 5.58 (±0.17) |
| MARSY | 0.780 (±0.010) | 0.886 (±0.005) | 5.36 (±0.19) | 0.749 (±0.011) | 0.875 (±0.005) | 5.62 (±0.15) |
| MatchMaker | 0.742 (±0.004) | 0.873 (±0.006) | 6.11 (±0.32) | 0.720 (±0.006) | 0.864 (±0.007) | 6.23 (±0.12) |
| TreeCombo | 0.737 (±0.004) | 0.870 (±0.003) | 5.73 (±0.17) | 0.689 (±0.005) | 0.856 (±0.006) | 6.00 (±0.15) |
| DeepSynergy | 0.701 (±0.003) | 0.869 (±0.004) | 5.78 (±0.18) | 0.676 (±0.006) | 0.860 (±0.008) | 5.95 (±0.16) |
a
The best performing scores were highlighted in bold, and the arrow indicates whether the measure is maximized or minimized.