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Cytochrome P450 phenotyping and inhibition by ELP‐004.
| Isoform | CYP1A2 | CYP2B6 | CYP2C8 | CYP2C9 | CYP2C19 | CYP2D6 | CYP3A4 |
|---|---|---|---|---|---|---|---|
| ELP‐004 t 1/2 (min) | 9.73 | 8.51 | 127 | >180 | 99.2 | >180 | 143 |
| Recombinant CYP CLINT (μL/min/mg) | 2.85 | 0.815 | 0.219 | <0.154 | 0.279 | <0.154 | 0.193 |
| Inhibition IC50 (μM) | >25 | >25 | >25 | >25 | >25 | >25 | >25 a |
Abbreviation: CLINT, intrinsic clearance.
Midazolam and testosterone.
