Table 2.
Main Clinical, Biological, and Radiological Characteristics of the Patients With Diffuse Low-Grade Glioma at TMZ Initiation
| Sex | |
|---|---|
| Male, n (%) | 15 (57.7) |
| Female, n (%) | 11 (42.3) |
| Tumor side | |
| Right hemisphere, n (%) | 6 (23.1) |
| Left hemisphere, n (%) | 20 (76.9) |
| Tumor location | |
| Frontal, n (%) | 4 (15.4) |
| Temporal +/− insular, n (%) | 5 (19.2) |
| Fronto-insular, n (%) | 5 (19.2) |
| Fronto-temporo-insular, n (%) | 6 (23.1) |
| Parietal, n (%) | 6 (23.1) |
| Histological-molecular diagnosis (WHO 2016) | |
| Oligodendroglioma, mutant IDH and 1p19q codeled, n (%) | 12 (46.1) |
| Diffuse astrocytoma, mutant IDH, n (%) | 13 (50.0) |
| Diffuse astrocytoma, wild-type IDH, n (%) | 1 (3.8) |
| Foci of malignant transformation within an otherwise grade 2 tumor, n (%) | 2 (7.7) |
| Number of previous surgeries | |
| 1, n (%) | 21 (80.8) |
| 2, n (%) | 4 (15.4) |
| 3, n (%) | 1 (3.8) |
| Surgery type before TMZ initiation (awake in 25/26 patients) | |
| Subtotal, n (%) | 25 (96.1) |
| Partial, n (%) | 1 (3.8) |
| In awake conditions, n (%) | 25 (96.1) |
| Median age in years at baseline (range) | 45 (29–73) |
| Median time after last surgery in months (range) | 36 (1–96) |
| Median time after diagnosis in months (range) | 47 (4–121) |
| Personal situation | |
| Single, widow or divorced n (%) | 5 (19.2) |
| Married/cohabiting, n (%) | 21 (80.8) |
| Professional situation | |
| Full-time work, n (%) | 10 (38.5) |
| Part-time work, n (%) | 6 (23.1) |
| Permanent disability, n (%) | 6 (23.1) |
| Sick leave, n (%) | 1 (3.8) |
| No activity, n (%) | 1 (3.8) |
| Sociocultural level | |
| Years of study, median (range) | 14 (8–22) |
| Sociocultural level, 30 n (%) | |
| 2 | 3 (11.5) |
| 3 | 14 (53.8) |
| 4 | 9 (34.6) |
| ECOG performance status score | |
| 0, n (%) | 15 (57.7) |
| 1, n (%) | 11 (42.3) |
| Epileptic seizures | |
| Any type, n (%) | 12 (46.2) |
| Partial, n (%) | 11 (42.3) |
| Generalized, n (%) | 2 (7.7) |
| Median tumor volume (cm3) on FLAIR-weighted sequence (range) | 18.6 (2.5–38.8) |
FLAIR, fluid attenuation inversion recovery.