Table 3.

Clinical Trials of Exosomes in Bone Cancer

Clinical trial ID	Sponsor	Responsible party	Summary
NCT03108677	Ruijin Hospital	Yuhui Shen, Ruijin Hospital	To investigate the use of circulating exosome RNA profiles as biomarkers for lung metastases in primary high-grade osteosarcoma. Researchers have found significant differences in circulating exosome RNA levels and mutations between patients with and without lung metastasis.
NCT05101655	Ruijin Hospital	Ruijin Hospital	The development of exosome microfluidic chips for early diagnosis of osteosarcoma lung recurrence and monitoring the response to second-line therapy for recurrent osteosarcoma. The microfluidic chip technology aims to capture and quantify exosomes for biomarker screening.
NCT03895216	Istituto Ortopedico Rizzoli	Istituto Ortopedico Rizzoli	To identify deregulated miRNAs within circulating exosomes in oncological patients with bone metastases. The goal is to establish a panel of predictive biomarkers for bone metastasis risk and explore their therapeutic implications. The study involves various molecular screening methods and 3D culture experiments.