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. 2024 May 30;15(13):4060–4071. doi: 10.7150/jca.95148

Figure 4.

Figure 4

Fractionated 3×20 Gy irradiation-induced brain damage in both Hif-1α+/- heterozygote and wild-type mice. (A) Representative T2* images and microhemorrhage assessment for Hif-1α+/- heterozygote and wild-type mice receiving fractionated 3×20 Gy radiation. More microhemorrhage lesions were observed in Hif-1α+/- heterozygote mice (blue arrow). (B) Representative T1-weighted gadolinium-enhanced MRI and BBB status for mice receiving fractionated radiation. Fractionated 3×20 Gy radiation-induced BBB breakdown at 63 weeks after radiation (hyperintensity, arrowhead) and more extensive BBB breakdown was observed in Hif-1α+/- heterozygote mice. (C) Representative T2-weighted MR images and anatomical analysis for mice receiving fractionated radiation. Ipsilateral lateral ventricle compression was observed at 63 weeks after radiation in wildtype mice (red arrow) and Hif-1α+/- mice (blue arrow), with more severe in Hif-1α+/- heterozygote mice. N=3 mice per group (3 slices for each mouse). Wildtype group: ANOVA, */**P<0.05/0.01. Hif-1α+/- group: ANOVA, #/##P<0.05/0.01. Wildtype vs. Hif-1α+/- group: Student t-test, &P<0.05.