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. 2024 Jun 28;16:142. doi: 10.1186/s13195-024-01516-6

Table 1.

Diagnostic criteria used in this study to operationalize the ‘MCI exclusion criterion’ within the SCD research criteria

Winblad [13] MCI criteria used in the Essex Memory Clinic Jak/Bondi [14] MCI criteria used for this study

1) Not normal, not demented (Does not meet criteria (DSM-IV, ICD-10) for a dementia syndrome)

2) Cognitive decline

a. Self and/or informant report and impairment on objective cognitive tasks* and/or

b. Evidence of decline over time on objective cognitive tasks

3) Preserved basic activities of daily living/minimal impairment in complex instrumental functions

1) General cognitive and functional performance sufficiently preserved such that a diagnosis of dementia cannot be made

2) Cognitive decline

a. Both scores fall more than 1 SD below the age-specific normative mean within a cognitive domain; or

b. One score falls more than 1 SD below the age-specific normative mean in all of the cognitive domains sampled

The Winblad criteria [13] are reproduced with permission from John Wiley and Sons. The Jak/Bondi criteria [14] are reproduced with permission from IOS Press. Abbreviations: MCI = mild cognitive impairment; DSM-IV = Diagnostic and Statistical Manual of Mental Disorders (4th edition); ICD-10 = International Statistical Classification of Diseases and Related Health Problems (10th Revision). *Whilst, for Winblad criteria, the clinic does not apply a rigid cut-off to classify MCI, cognitive scores falling below the 10th percentile (according to demographically-adjusted norms) are typically interpreted as impaired.