Table 3.

The multivariate analysis for Grade 3–4 cell toxicity

	OR (95% CI)	P value	Q value
ALC
Group		0.001	0.002
All lower (EDIC ≤ 4.63 Gy, V10 ≤ 140.3 ml)	0.050 (0.010–0.251)	< 0.001	0.001
Others	0.134 (0.025–0.726)	0.020	0.026
All higher (EDIC > 4.63 Gy, V10 > 140.3 ml)	Ref
Tumor location
Upper	0.912 (0.317–2.264)	0.864	0.864
Middle + Distal	Ref
WBC
Group		0.021	0.041
All lower (EDIC ≤ 4.53 Gy, V10 ≤ 100.9 ml)	0.177 (0.047–0.688)	0.011	0.041
Others	0.449 (0.165–1.225)	0.118	0.157
All higher (EDIC > 4.53 Gy, V10 > 100.9 ml)	Ref
Age
≤ 60 years	1.611 (0.681–3.810)	0.278	0.278
> 60 years	Ref
NEU
Group
Lower (EDIC ≤ 5.79 Gy)	0.401 (0.175–0.922)	0.031	0.037
Higher (EDIC > 5.79 Gy)	Ref
Chemotherapy regimen
FP	0.191 (0.040–0.902)	0.037	0.037
TP	Ref

ALC absolute lymphocyte count; WBC white blood cell count; NEU neutrophil count; EDIC effective dose to immune cells; Q values adjusted P values using Benjamini-Hochberg false discovery rate (FDR) correction for multiple hypothesis testing