TABLE 13.
Name of the study | Year of the study | Phase of the study | Research group | Dose | Results |
---|---|---|---|---|---|
Kershaw et al. (Kershaw et al., 2006) | 2006 | I | 14 | 3 × 109–5 × 1,010 transduced T cells | There were observed some grade 3 and 4 toxicities in the group with high-dose usage of IL-2; in the group, which received T cells without IL-2, patients experienced relatively mild side effects; there was not observed any tumor burden in patients |
Dobrzanski et al. (Dobrzanski et al., 2012) | 2012 | Phase I/II | 7 | 108–109 T cells per infusion (i.e. 1–4 × 108 cells/m2) | There was observed enhanced patient survival in 3 monthly treatment cycles (3->84 months) |
IL, interleukin.