Table 2.
Association between heparin use and clinical outcomes
|
|
Heparin-free group, n (%)
|
Heparin group, n (%)
|
OR (95%CI)
|
P value
|
| Before PSM | n = 421 | n = 967 | ||
| PHLF | 66 (15.7) | 76 (7.9) | 2.180 (1.533, 3.099) | < 0.001 |
| ICU stay | 79 (18.8) | 129 (13.3) | 1.501 (1.104, 2.040) | 0.010 |
| Respiratory support | 70 (16.6) | 72 (7.4) | 2.479 (1.745, 3.523) | 0.000 |
| CRRT | 17 (4) | 8 (0.8) | 5.044 (2.160, 11.782) | < 0.001 |
| Hypoxemia | 39 (9.3) | 48 (5.0) | 1.955 (1.260, 3.032) | 0.003 |
| AKI | 40 (9.5) | 66 (6.8) | 1.433 (0.951, 2.161) | 0.086 |
| ICU death | 43 (10.2) | 43 (4.4) | 2.354 (1.543, 3.593) | < 0.001 |
| After PSM | n = 213 | n = 213 | ||
| PHFL | 45 (21.1) | 28 (13.1) | 0.530 (0.303, 0.928) | 0.026 |
| ICU stay | 49 (23.0) | 51 (23.9) | 1.722 (0.933, 3.177) | 0.082 |
| Respiratory support | 43 (20.2) | 30 (14.1) | 0.502 (0.262, 0.960) | 0.037 |
| CRRT | 5 (2.3) | 4 (1.9) | 1.059 (0.249, 4.496) | 0.939 |
| Hypoxemia | 23 (10.8) | 23 (10.8) | 1.181 (0.598, 2.334) | 0.631 |
| AKI | 22 (10.3) | 21 (9.9) | 1.017 (0.525, 1.971) | 0.960 |
| ICU death | 27 (12.7) | 24 (11.3) | 0.956 (0.469, 1.949) | 0.901 |
Bivariate logistic regression analysis with patients before and post propensity score matching was all applied to investigate variables potentially associated with all secondary clinical outcomes. PSM: Propensity score matching; CRRT: Continuous renal replacement therapy; PHFL: Post-hepatectomy liver failure; AKI: Acute kidney injury.