Table 3.
Univariate and multivariate analyses of factors associated with liver failure in matched groups
|
Factors
|
B
|
SE
|
Wald
|
OR (95%CI) |
P value
|
| Univariate | |||||
| Heparin | -0.571 | 0.263 | 4.703 | 0.565 [0.337, 0.947] | 0.030 |
| Gender | -0.231 | 0.267 | 0.749 | 0.794 [0.470, 1.340] | 0.387 |
| Age | -0.009 | 0.008 | 1.099 | 0.991 [0.975, 1.008] | 0.294 |
| Height | 0.021 | 0.014 | 2.055 | 1.021 [0.992, 1.050] | 0.152 |
| Weight | 0.026 | 0.008 | 9.392 | 1.026 [1.009, 1.043] | 0.002 |
| Malignant tumor | -0.169 | 0.287 | 0.347 | 0.845 [0.482, 1.481] | 0.556 |
| Laparoscopic | -0.802 | 0.468 | 2.929 | 0.449 [0.179, 1.123] | 0.087 |
| Smoking | 0.032 | 0.252 | 0.016 | 1.032 [0.630, 1.691] | 0.900 |
| Ethnicity | -0.361 | 0.274 | 1.732 | 0.697 [0.407, 1.193] | 0.188 |
| Hypertension | 0.085 | 0.258 | 0.108 | 1.088 [0.656, 1.804] | 0.743 |
| PVTT | 1.207 | 0.426 | 8.003 | 3.343 [1.451, 7.703] | 0.005 |
| Diabetes | 0.891 | 1.232 | 0.523 | 2.437 [0.218, 27.243] | 0.469 |
| Cirrhosis | 0.635 | 0.276 | 5.319 | 1.888 [1.100, 3.239] | 0.021 |
| Portal hypertension | 0.854 | 0.310 | 7.579 | 2.348 [1.279, 4.312] | 0.006 |
| COPD | 0.389 | 0.631 | 0.380 | 0.678 [0.197, 2.334] | 0.537 |
| CKD | 0.465 | 0.388 | 1.440 | 1.592 [0.745, 3.404] | 0.230 |
| Transfusion | 1.565 | 0.275 | 32.311 | 4.783 [2.788, 8.205] | 0.000 |
| Laboratory tests | |||||
| TBIL | 0.068 | 0.017 | 15.985 | 1.070 [1.035, 1.107] | 0.000 |
| AST | 0.000 | 0.000 | 2.462 | 1.000 [1.000, 1.001] | 0.117 |
| ALT | 0.000 | 0.000 | 0.308 | 1.000 [1.000, 1.001] | 0.579 |
| LDH | 0.000 | 0.000 | 3.279 | 1.000 [1.000, 1.000] | 0.070 |
| ALB | -1.020 | 0.218 | 21.989 | 0.360 [0.235, 0.552] | 0.000 |
| Cr | 0.054 | 0.105 | 0.264 | 1.056 [0.859, 1.298] | 0.608 |
| BUN | -0.005 | 0.008 | 0.457 | 0.995 [0.979, 1.010] | 0.499 |
| GFR | -0.005 | 0.008 | 0.457 | 0.995 [0.979, 1.010] | 0.499 |
| WBC | 0.025 | 0.016 | 2.278 | 1.025 [0.993, 1.058] | 0.131 |
| PLT | -0.006 | 0.002 | 13.876 | 0.994 [0.991, 0.997] | 0.000 |
| INR | 0.529 | 0.158 | 11.266 | 1.697 [1.246, 2.312] | 0.001 |
| PT | 0.049 | 0.014 | 11.643 | 1.050 [1.021, 1.081] | 0.001 |
| APTT | 0.010 | 0.007 | 1.797 | 1.010 [0.996, 1.024] | 0.180 |
| Multivariate | |||||
| Heparin | -0.657 | 0.287 | 5.236 | 0.518 [0.295, 0.910] | 0.022 |
| PVTT | 1.342 | 0.482 | 7.734 | 3.825 [1.486, 9.844] | 0.005 |
| Transfusion | 1.199 | 0.297 | 16.248 | 3.316 [1.851, 5.940] | < 0.000 |
| TBIL | 0.048 | 0.019 | 6.558 | 1.050 [1.011, 1.089] | 0.010 |
| ALB | -0.749 | 0.239 | 9.815 | 0.473 [0.296, 0.755] | 0.002 |
The initial screening via univariable logistic regression analysis; all variables with P < 0.1 are considered as potential risk factors, and then allowed in the multivariable analysis with a backward stepwise selection process. Factors with P < 0.05 (the bold) in the final multivariate model means significance. PVTT: Portal vein tumor thrombus; PSM: Propensity score matching; COPD: Chronic obstructive pulmonary disease; CKD: Chronic kidney disease; RBC: Red blood cell; TBIL: Total bilirubin; AST: Aspartate transaminase; ALT: Alanine transaminase; LDH: Lactate dehydrogenase; ALB: Albumin; Cr: Serum creatinine; BUN: Blood urea nitrogen; GFR: Glomerular filtration rate; WBC: White blood cell; INR: International normalized ratio; PLT: Platelets; PT: Prothrombin time; APTT: Activated partial thromboplastin time.