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. 2023 Nov 23;136(1):109–121. doi: 10.1152/japplphysiol.00337.2023

Figure 3.

Figure 3.

Representative images of mouse gastrocnemius muscle showing myosin heavy chain (MHC) expression (A and B) as well as succinate dehydrogenase (SDH) activity staining (C) and glyceraldehyde-3-phosphate dehydrogenase activity (GPD) staining (D). Bubble plots (E–G) show SDH activity, GPD activity, and cross-sectional area (CSA) for each fiber type in mouse, rat, and human skeletal muscles. Bubble size represents the relative CSA within a species. SDH and GPD activity are expressed relative to the values obtained in type I fibers (soleus for mouse and rat, vastus lateralis for human) and assigned a reference value of 1.0. There are significant variations and overlap between characteristics of fibers across experiments, species, and muscles. Adapted from Bloemberg et al. (90).