Fig. 4 |. Micro RNA expression pattern in PBMCs from SHIP AHOY participants with mid-BP, high-BP, and high-BP+high-LVMI.

Volcano Plot representing differentially expressed miRNAs in mid-BP group (A), high-BP group (B), and high-BP+high-LVMI group (C), each compared to their respective controls. MicroRNAs with changes in expression and their p-value are determined by DEseq2 algorithm. The red color represents the increased miRNA expression, and the blue represents the diminished miRNA expression with p-value <0.05 and an absolute value of log₂ fold change cut off 0.5. The top 3 up-regulated and down-regulated miRNAs were labeled for each analysis. The upregulated and downregulated miRNAs are compared among mid-BP, high-BP and high-BP+high-LVMI groups. D-E, Venn diagrams showing the upregulated set of miRNAs with a p-value<0.05 (D), and downregulated set of miRNAs with a p-value<0.05 (E).

BP: Blood pressure; LVMI: Left ventricular mass index; miRNA: MicroRNAs; PBMCs: Peripheral blood mononuclear cells; SHIP AHOY = Study of High Blood Pressure in Pediatrics: Adult Hypertension Onset in Youth