Fig. 8 |. Proposed mechanism of target organ injury in youth with high blood pressure.

Based on the RNA, miRNA, and methylation sequencing and proteomic analysis of mid-BP, high-BP and high-BP+high-LVMI youth subjects, anti-angiogenic stimuli and ECM degradation through the signals from PBMCs and circulating proteins leads to target organ injury. Rectangular boxes are the genes and miRNAs displaying differential transcript level in PBMCs; oval boxes represent differential protein levels in circulation; cylindrical boxes represent genes differentially expressed in PBMCs and proteins differentially expression in circulation. Red color represents up-regulation and blue color indicates down-regulation (Figure Created with BioRender.com).