Table 9.
Functional enrichment of significantly dysregulated serum proteins (Differentially expressed proteins; DEPs) among mid-BP and high-BP+high-LVMI group SHIP AHOY participants.
| Category | Term | Description | LogP | Log(q-value) | Percentage of DEP genes enriched |
|---|---|---|---|---|---|
|
| |||||
| Mid-BP DEPs | |||||
| Reactome Gene Sets | R-HSA-977606 | Regulation of Complement cascade Regulation of Insulin-like Growth Factor |
−9.73 | −5.47 | 10.64 |
| Reactome Gene Sets | R-HSA-381426 | (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | −9.51 | −5.47 | 5 |
| GO Biological Processes | GO:0042060 | Wound healing | −2.83 | −0.20 | 0.95 |
|
| |||||
| High-BP+high-LVMI DEPs | |||||
| GO Biological Processes | GO:0006954 | Inflammatory response | −8.47 | −4.43 | 1.42 |
| GO Biological Processes | GO:0009611 | Response to wounding | −6.36 | −3.13 | 1.42 |
| GO Biological Processes | GO:0042060 | Wound healing | −5.57 | −2.45 | 1.58 |
| GO Biological Processes | GO:1990266 | Neutrophil migration | −4.40 | −1.61 | 3.26 |
| GO Biological Processes | GO:0097530 | Granulocyte migration Regulation of Insulin-like Growth Factor |
−4.29 | −1.55 | 3 |
| Reactome Gene Sets | R-HSA-381426 | (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | −4.00 | −1.27 | 2.4 |
| WikiPathways | WP5095 | Overview of proinflammatory and profibrotic mediators | −3.96 | −1.26 | 2.33 |
| GO Biological Processes | GO:0000302 | Response to reactive oxygen species | −3.54 | −0.93 | 1.68 |
| Reactome Gene Sets | R-HSA-1474244 | Extracellular matrix organization | −2.89 | −0.38 | 1 |
| GO Biological Processes | GO:0006979 | Response to oxidative stress | −2.65 | −0.18 | 0.83 |