Table 2.
Validation of reported loci for cross-sectional THR
| rsID | chr | pos | Locus | role | CA | Non_CA | eaf | LLFS |
Oliveri et al |
||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| β | SE | P | β | SE | P | ||||||||
| rs10889333 | 1 | 62491359 | ANGPTL3 | intronic | A | G | 0.328 | −0.124 | 0.043 | 3.70E-03 | −0.066 | 0.003 | 3.37E-89 |
| rs13094241 | 3 | 196464022 | UBXN7-AS1 | intergenic | T | G | 0.262 | 0.096 | 0.046 | 3.61E-02 | 0.021 | 0.003 | 5.11E-09 |
| rs998584 | 6 | 43790159 | VEGFA | intergenic | A | C | 0.489 | 0.088 | 0.039 | 2.44E-02 | 0.062 | 0.003 | 8.55E-86 |
| rs12208357 | 6 | 160122116 | SLC22A1 | nonsynonymous_SNV | T | C | 0.068 | 0.168 | 0.078 | 3.04E-02 | 0.042 | 0.005 | 1.44E-11 |
| rs17145750 | 7 | 73612048 | MLXIPL | intronic | T | C | 0.167 | −0.110 | 0.054 | 4.28E-02 | −0.142 | 0.004 | 2.76E-241 |
| rs111914893 | 7 | 74587994 | GTF2IRD1 | intronic | T | C | 0.062 | 0.226 | 0.081 | 5.16E-03 | 0.041 | 0.006 | 1.51E-08 |
| rs10260148 | 7 | 130746210 | KLF14 | intergenic | T | C | 0.268 | 0.114 | 0.045 | 1.07E-02 | 0.043 | 0.003 | 9.46E-35 |
| rs62492368 | 7 | 150840547 | AOC1 | intergenic | A | G | 0.320 | 0.099 | 0.042 | 2.02E-02 | 0.022 | 0.003 | 8.89E-11 |
| rs7012814 | 8 | 9315848 | LOC157273 | intergenic | A | G | 0.468 | −0.113 | 0.040 | 5.35E-03 | −0.038 | 0.003 | 2.07E-33 |
| rs268 | 8 | 19956018 | LPL | nonsynonymous_SNV | G | A | 0.018 | 0.584 | 0.151 | 1.11E-04 | 0.292 | 0.010 | 1.11E-136 |
| rs73667496 | 8 | 20080341 | LPL,SLC18A1 | intergenic | T | C | 0.060 | −0.232 | 0.084 | 6.04E-03 | −0.099 | 0.006 | 6.59E-44 |
| rs7015766 | 8 | 20081538 | LPL,SLC18A1 | intergenic | T | C | 0.076 | −0.251 | 0.077 | 1.13E-03 | −0.263 | 0.005 | 8.39E-405 |
| rs6999569 | 8 | 125463528 | TRIB1 | intergenic | G | A | 0.488 | −0.106 | 0.041 | 9.19E-03 | −0.108 | 0.003 | 6.83E-258 |
| rs9919491 | 10 | 92995002 | EXOC6 | intronic | A | T | 0.275 | 0.103 | 0.047 | 2.98E-02 | 0.021 | 0.003 | 2.64E-09 |
| rs480823 | 11 | 116655013 | LINC02702 | ncRNA_intronic | C | T | 0.083 | 0.262 | 0.071 | 2.44E-04 | 0.206 | 0.005 | 2.09E-267 |
| rs117233107 | 12 | 4219355 | CCND2 | intergenic | A | G | 0.019 | −0.525 | 0.146 | 3.32E-04 | −0.088 | 0.011 | 9.84E-11 |
| rs72735627 | 15 | 40765309 | GCHFR | UTR3 | T | C | 0.120 | −0.149 | 0.062 | 1.70E-02 | −0.032 | 0.004 | 1.85E-09 |
| rs139974673 | 15 | 43735687 | MAP1A | downstream | C | T | 0.034 | 0.296 | 0.112 | 8.27E-03 | 0.197 | 0.008 | 2.51E-88 |
| rs72786786 | 16 | 56951602 | HERPUD1 | intergenic | A | G | 0.331 | −0.090 | 0.041 | 2.94E-02 | −0.151 | 0.003 | 4.12E-421 |
| rs7499892 | 16 | 56972678 | CETP | intronic | T | C | 0.169 | 0.162 | 0.053 | 2.33E-03 | 0.171 | 0.003 | 2.15E-381 |
| rs931992 | 17 | 39665182 | STARD3 | upstream;downstream | G | T | 0.344 | 0.096 | 0.042 | 2.28E-02 | 0.020 | 0.003 | 8.65E-10 |
| rs116843064 | 19 | 8364439 | ANGPTL4 | nonsynonymous_SNV | A | G | 0.024 | −0.441 | 0.131 | 7.67E-04 | −0.260 | 0.009 | 5.57E-116 |
| rs58542926 | 19 | 19268740 | TM6SF2 | nonsynonymous_SNV | T | C | 0.081 | −0.224 | 0.073 | 2.14E-03 | −0.108 | 0.005 | 7.28E-74 |
| rs185799410 | 20 | 58891038 | GNAS | intronic | T | G | 0.028 | 0.263 | 0.121 | 3.02E-02 | 0.056 | 0.008 | 2.57E-08 |
| rs2223041 | 21 | 15050282 | NRIP1 | intronic | T | C | 0.386 | 0.123 | 0.042 | 3.74E-03 | 0.018 | 0.003 | 5.00E-08 |
chr = chromosome number
pos = base pair positions
Locus = mapped gene locus
CA = the allele used to estimate the effect
Non_CA = the other allele not used for estimation of the effect
eaf = the frequency of coded allele
β = the effect estimate
SE = Standard Error
P = two-sided P value