Figure 2.
SNP-based heritability and genetic correlation analysis comparisons across cannabis-related traits. A) Genetic correlations and h2SNP across 23andMe lifetime cannabis use and frequency of cannabis use with ICC lifetime cannabis use 34 and CUD from Levey et al. 22. h2SNP±standard error shown in matrix diagonal (gray boxes), rg±standard error in off-diagonal (white boxes). Correlation coefficients shown in heatmap color, with p value underneath in black. B) CUD requires progression through multiple pre-addiction stages, including experimental use, regular use, compulsive/harmful use, dependence, cessation attempts, and relapse. Aside from lifetime cannabis use as a proxy for experimental use and frequency of cannabis use as a proxy for regular use, which positively genetically correlate with CUD, most of these stages have not been genetically explored with GWAS.