Table 1.

Joint-PGS regression analysis associating lifetime cannabis use PGS, frequency of cannabis use PGS, and select covariates with lifetime, daily, and problematic cannabis use in AoU cohorts. Bold PGS results are significant following Bonferroni correction (p<8.33E-03). For full analysis variables, see Supplementary Table 16.

	European Cohort									African Cohort
	Lifetime Use (Ncase=64,711, Ncontrol=49,595)			Daily Use (Ncase=1,411, Ncontrol=28,112)			Problematic Use (Ncase=1,825, Ncontrol=118,704)			Lifetime Use (Ncase=26,064, Ncontrol=21,610)			Daily Use (Ncase=2,483, Ncontrol=11,718)			Problematic Use (Ncase=2,315, Ncontrol=50,262)
Variable	β	StdErr	p	β	StdErr	p	β	StdErr	p	β	StdErr	p	β	StdErr	p	β	StdErr	p
Lifetime PGS	0.19	0.01	<2.00E-16	0.09	0.03	5.09E-04	0.22	0.02	<2.00E-16	0.08	0.01	2.76E-12	−0.02	0.03	0.52	3.62E-03	0.02	0.88
Frequency PGS	0.06	0.01	<2.00E-16	−0.03	0.03	0.38	0.06	0.03	0.01	0.04	0.01	1.88E-04	0.03	0.03	0.23	0.01	0.03	0.61