Fig. 5: The SARS-CoV-2-nsp5^T169Insp12^V792I virus showed efficient transmission to contact golden Syrian hamsters.

(A) Experimental design. (B) Changes in body weight of hamsters following intranasal inoculation of SARS-CoV-2-nsp5^T169Insp12^V792I and WT viruses and in contact animals throughout the 14-day experimental period. (C) SARS-CoV-2 RNA load in oropharyngeal swabs quantified by rRT-PCR. (D-E). Infectious SARS-CoV-2 loads in oropharyngeal swabs determined using endpoint dilutions and expressed as TCID₅₀.mL⁻¹. (F) SARS-CoV-2 RNA load in nasal turbinate, trachea and lungs quantified by rRT-PCR. (G) Neutralizing antibody responses to SARS-CoV-2 assessed by virus neutralization assay (100% neutralization) in serum. Data represents mean ± SEM (B-C) and median (D-G) of four animals per group per time point.