FIG. 4.

TEM of HSV-1-infected Vero cells. Vero cells were infected with KOS (A), 8MA (B), or 8MA/ΔSma (C and D) at an MOI of 5 for 24 h. Within 8MA- and 8MA/ΔSma-infected cells, empty and full capsids are observed within the cytoplasm (thin arrows), while enveloped capsids accumulate within the perinuclear space (thick arrows). 8MA/ΔSma-infected cell nuclei often harbor enveloped virions within nuclear vacuoles believed to result from cross-sectioning of invaginated nuclear membranes (open arrow). Bar, 0.5 μm (panel D).