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Lgr4 deficiency altered bile acids synthesis and transport in hepatocytes. A: total bile acids of liver and serum, total bilirubin of serum. B: mRNA levels of bile acids synthesis. C: mRNA levels of bile acids transports. Results are presented as means ± SE and analyzed by two-way ANOVA and unpaired Student’s t test, n = 6, * and #P < 0.05, *P < 0.05, comparison with Sham-Lgr4fl/fl; #P < 0.05, comparison with BDL-Lgr4fl/fl. BDL, bile duct ligation.
