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. 2024 May 14;134(13):e174500. doi: 10.1172/JCI174500

Figure 2. CFTR loss impairs metabolism in multiple organs and interorgan metabolite exchange.

Figure 2

(A) Schematic of the circulatory system indicating blood and urine sampling sites. (B) For each organ in WT and CF pigs, metabolites showing significant release and uptake were identified using the 1-sample t test or Mann-Whitney U test (see Supplemental Table 2). (C) Schematic plotting the source and sink organs of circulating metabolites. The blunt end indicates source organ X, and the arrowed end indicates sink organ Y. Numbers indicate the number of metabolite exchange events that met statistical significance in both organs for each interorgan metabolite exchange. (D) Chord graphs indicating metabolite exchange between organs in WT and CF pigs. n = 9 WT and n = 10 CF pigs.