Table 1.
Summary of the genome-wide significant risk loci for EOCRC represented by the lead SNP in each locus
| rsID | Cytoband | Chr | Pos (hg37) | Alt/Risk | RAF | OR (95% CI) | PGWAS | BFDP | I2 | Phet |
|---|---|---|---|---|---|---|---|---|---|---|
| New loci | ||||||||||
| rs186107317 | 1p34.1 | 1 | 46045280 | T/A | 0.008 | 1.82 (1.32-1.2.86) | 2.35 × 10–08 | 8.16 × 10–19 | 0.0 | 0.82 |
| rs9991540 | 4p15.33 | 4 | 14881360 | G/C | 0.09 | 1.2 (1.14-1.27) | 2.28 × 10–08 | 6.66 × 10–05 | 0.0 | 0.68 |
| Known loci | ||||||||||
| rs16892766 | 8q23.3 | 8 | 117630683 | A/C | 0.09 | 1.33 (1.22-1.45) | 3.56 × 10–18 | 1.01 × 10–24 | 0.0 | 0.68 |
| rs10808556 | 8q24.21 | 8 | 128413147 | T/C | 0.41 | 1.14 (1.08-1.19) | 3.07 × 10–10 | 7.18 × 10–06 | 39.8 | 0.17 |
| rs11255835 | 10p14 | 10 | 8732887 | C/A | 0.45 | 0.88 (0.84-0.92) | 1.82 × 10–09 | 6.42 × 10–05 | 0.0 | 0.89 |
| rs7944895 | 11q23.1 | 11 | 111167776 | G/C | 0.30 | 1.14 (1.1-1.19) | 2.60 × 10–10 | 3.06 × 10–06 | 0.0 | 0.52 |
| rs12427378 | 12q13.12 | 12 | 51074199 | T/C | 0.34 | 1.14 (1.09-1.19) | 2.76 × 10–10 | 4.31 × 10–06 | 34.0 | 0.21 |
| rs73376930 | 15q13.3 | 15 | 33012502 | A/G | 0.21 | 1.28 (1.20-1.35) | 7.05 × 10–25 | 3.39 × 10–33 | 0.0 | 0.70 |
| rs11874392 | 18q21.1 | 18 | 46453156 | T/A | 0.45 | 1.19 (1.15-1.23) | 1.27 × 10–18 | 4.66 × 10–19 | 77.7 | 0.004 |
| rs913245 | 20p12.3 | 20 | 6382301 | A/G | 0.32 | 1.12 (1.08-1.18) | 1.43 × 10–08 | 0.001 | 0.0 | 0.76 |
| rs6066825 | 20q13.13 | 20 | 47340117 | A/G | 0.38 | 0.87 (0.84-0.90) | 7.13 × 10–11 | 4.64 × 10–07 | 0.0 | 0.40 |
| rs2427291 | 20q13.33 | 20 | 60921324 | G/A | 0.20 | 0.85 (0.8-0.9) | 9.69 × 10–10 | 2.81 × 10–06 | 0.0 | 0.78 |
Alt, alternative/other allele; BFDP, Bayesian false-discovery probability; Chr, chromosome; CI, confidence interval; EOCRC, early-onset colorectal cancer; GWAS, genome-wide association study; I2, proportion of the total variation due to heterogeneity; OR, odds ratio calculated for risk allele; PGWAS, P-value from GWAS meta-analysis; Phet, P-value for heterogeneity across studies; Pos, base position; RAF, risk allele frequency; Risk, risk allele; SNP, single-nucleotide polymorphism.