Fig. 1. The phylogenetic structure of historical S. Typhi isolates.
a A phylogenetic overview of historical (1980–1995) S. Typhi from the UKHSA. Maximum likelihood outgroup rooted phylogenetic tree depicting the genomic sequences of 463 S. Typhi isolated from returning travellers to the United Kingdom between 1980 and 1995. Branch colour indicates genotype, and rings outside of the tree indicate country of origin, MDR, and presence of IncH1 plasmid, coloured as per the inset legend. Individual mutations in the quinolone resistance determining region (QRDR) indicated by stars outside the rings. b A phylogenetic overview of historical H58 (4.3.1) S. Typhi isolates. Zoomed-in view of H58 S. Typhi isolates from historical collection. Genotype, country of origin, presence of MDR, AMR mutations, and presence of IncH1 plasmids are indicated by bars to the right of the tree and coloured as per the inset legend. Individual mutations in the quinolone resistance determining region (QRDR) indicated by stars to the right of the bars. c A bar graph showing distribution of samples by year (1980–1995) and countries of origin are indicated by colour as per inset legend.
