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Overlap of binding sites. Overlap of the CHOL, PIP2, POPC, and POSM binding sites (transparent yellow surfaces), resolved by CGMD simulations of AE1IF-IF, AE1OF-OF, NBCe1, and NDCBE and presented in Figure 4, with the available cryo-EM structures of OF SLC4A11, OF AE1, and IF AE1 reported with bound cholesterol (red sticks), PIP2 (magenta sticks), and phospholipids (blue sticks). To see this figure in color, go online.
