Agrawal 2009.
Methods | Prospective, randomised, placebo‐controlled, single centre study | |
Participants | 150 patients ( 50 alfuzosin, 50 tamsulosin, 50 placebo), mean age 69, 72 and 71 years respectively (aged 48 to 90 years) | |
Interventions | A (50): Alfuzosin 10 mg OD B (50): Tamsulosin 0.4 mg C (50): Placebo, Then TWOC after 3 days |
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Outcomes | Number who had successful TWOC: A 33/50, B 35/50, C 18/50 Initial catheterisation volume American Urological Association score Post void residual urinary volume (mL) Peak urinary flow rate (mL/sec) Adverse effects |
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Notes | Second trial phase: successful TWOC patients continued in respective treatment groups and followed up at 1 week, 2 weeks, 1 month and 3 months. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Method of randomisation not specified: '...randomized into three groups.' |
Allocation concealment (selection bias) | Unclear risk | Not specified |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | More detail in tables of analysis needed. |
Selective reporting (reporting bias) | Unclear risk | All the outcomes as detailed in the method section of the trial were reported in the result section. Some outcomes which are considered important from patients’ perspective were not reported. Without the protocol it was difficult to judge whether or not these outcomes were included in the protocol and not reported in the report. |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Not specified |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Not specified |
Other bias | Unclear risk | Other aspects of trial design such as baseline comparability, sample size calculation, use of intention‐to‐treat analysis and financial support were inadequately or not at all specified. |